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Under physiological conditions, Nrf2 binds to Keap1 located in the cytoplasm to form a dimer, but after oxidative stress occurs, Keap1 undergoes conformational changes due to electrophilic or oxidative signal modification, thereby releasing Nrf2 into the cell nucleus (Liu et al., 2022b)

Accordingly, all mentioned examples imply the use of as prepared hydrophilic NCs with no surface modifications prior to their encapsulation

Peroxidative breakdown of phospholipids in human spermatozoa, spermicidal properties of fatty acid peroxides, and protective action of seminal plasma

[] However, the source of TNFSF14 in this study is unclear