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However, despite the encouraging evidence, gaps in our knowledge remain to be filled in order to fully understand the mechanisms connecting NNMT with MetS-related disorders and to develop clinical agents against NNMT

This study also suggested the protective effect NR supplementation had on alcohol-induced liver injury, whose mechanism could involve the gut microflora-bile acid axis

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Nicotinamide N-methyltransferase (NNMT) is a key enzyme located in the cytosolic milieu that catalyzes the transfer of methyl group from the co-factor S-(5-Adenosyl)-L-methionine (SAM) to substrates such as nicotinamide (NCA), pyridine, and related analogs, such as quinoline, isoquinoline, and the1,2,3,4 tetrahydroisoquinoline.aliphatic amine NNMT directly regulates the detoxification of endogenous and exogenous drugs/xenobiotics by the formation of methylated metabolic products, such as 1-methyl nicotinamide (1-MNA), methylated pyridiniums, and methylated related analogs