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Glucagon can directly stimulate somatostatin secretion, independently of insulin Studies have demonstrated that glucagon plays a role in stimulating insulin secretion by a direct effect on glucagon and GLP-1 receptors expressed on the beta cells [12, 14, 17]

In LSS, the expression of the E3 ubiquitin ligase Smurf1 is markedly elevated, which promotes fibrosis and oxidative stress in LF cells, contributing to the progression of LSS by facilitating the ubiquitination and degradation of NRF2 [112]

Lutchmansingh et al., PLOS One, 2018 Glutathione as redox biomarker in mitochondrial disease implications for therapy by G.M

J Biol Chem 275:62596266 Herschman HR (1996) Prostaglandin synthase 2