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Tissue damage, whether resulting in a sunburn or in thyroid cancer is caused by ionizing radiation

It has been studied for tissue repair and inflammation in many animal models

Circulating IGFBPs, especially IGFBP-3 and IGFBP-5, can combine with circulating IGFs and acid-unstable subunits produced by liver cells to create terpolymer complexes around 140 kDa, resulting in a prolonged half-life of IGFs in circulation that can slow down the movement of IGFs to tissues outside of blood vessels [89, 90]

In ALD, this bidirectional crosstalk is further amplified, wherein iron overload contributes to microbial dysbiosis and intestinal barrier dysfunction, while microbiota-mediated alterations in iron absorption through HIF-2 pathway aggravate hepatic injury