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Impaired BBB integrity Postmortem studies of AD patients and animal models have revealed cellular infiltration, including red blood cells [139], macrophages [140], and neutrophils [141], as well as capillary leakage of blood-derived components such as fibrin(ogen), IgG, albumin, thrombin, and hemosiderin [142,143,144,145]

This makes it a promising therapy for digestive disorders such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and leaky gut syndrome (intestinal permeability)

The primary outcome was clinician-assessed PTSD symptom severity (CAPS-5)

Timing can vary depending on the severity of symptoms, the underlying cause, diet, medications, stress levels, and whether the gut issue is inflammatory, infectious, structural, or functional