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REIMAGINE 4 a 68-week efficacy and safety phase 3 trial of once-weekly CagriSema 2.4 mg/2.4 mg versus once-weekly tirzepatide 15 mg in 1,000 adults with type 2 diabetes inadequately controlled with metformin with or without an SGLT2 inhibitor

2.4 mg was the dose advanced into Phase 3 because the efficacy/tolerability ratio peaked there

Get the details in our updated answer to the question: Is drinking coffee good or bad for heart health

Key Takeaways Vitamin B12 is essential for red blood cell production, nervous system health, and energy metabolism, but it doesnt directly fatten you up. Current evidence suggests B12 itself is unlikely to cause weight gain