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Teschke R, Uetrecht J (2021) Mechanism of idiosyncratic drug induced liver injury (DILI): Unresolved basic issues

Nat Rev Cardiol 15:457470

Figure 1 Upon successful engagement of their TCR and the costimulation molecule CD28, the T cell begins to switch toward an activated metabolic program, utilizing aerobic glycolysis, the phosphate pentose pathway (PPP), and glutaminolysis ( + T cells ( Calcium Mobilization Following TCR Ligation Having considered the modulation of cellular metabolism via TCR proximal signaling pathways, we now turn our attention to calcium mobilization, and how this signaling platform shapes the metabolic response in T cells