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The fibrosis stage on the second biopsy correlated with the initial KC iron score (=0.27

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ORF3a inhibits the formation of acidic autolysosomes by sequestration of the HOPS component VPS39

Copper is known to have many beneficial biological applications, including, as a few examples, stimulating the accumulation of collagen and elastin, increasing the rate of wound healing, and increasing the amount of collagen in skin (see, e.g., Maquart, F