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(8) Research has demonstrated that SAM is a universal methyl donor required for numerous cellular methylation reactions including DNA and histone methylation

Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease

Additionally, paclitaxel-resistant PCa cells often upregulate the expression of the antiapoptotic protein Bcl-2 and increase GSH levels, further enhancing antioxidant defense and resistance

In laboratory research models, GSH exerts its antioxidant activity through direct scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as through serving as an essential cofactor for glutathione peroxidase (GPx) enzymes, which catalyse the reduction of hydrogen peroxide and lipid hydroperoxides to non-toxic products