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doi: 10.1183/13993003.02245-2021 143 BucciarelliVNasiMBiancoFSeferovicJIvkovicVGallinaSet al

Newly developed immunoproteasome inhibitors (IPI) could selectively inhibit proteasomes of cells involved in graft rejection after transplantation, such as B and T lymphocytes and APCs, and regulate pro-inflammatory cytokines and the differentiation of helper T cells (110, 111)

Xu, B., Hu, S.Q., Chu, Y.C., Wang, S., Wang, R.Y., Nakagawa, S.H., Katsoyannis, P.G., and Weiss, M.A

This leads to disruption in motor functions, driven by mitochondrial dysfunction, aggregation of alpha-synuclein proteins into Lewy bodies, chronic neuroinflammation, and oxidative stress 33