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Cell culture studies indicated that the vitamin E ester, -tocopheryl succinate, could inhibit proliferation and induce apoptosis in a number of cancer cell lines (13)

GCN2 phosphorylates eIF2, leading to ATF4 induction and upregulation of downstream targets including CHAC1

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Moreover, the isolated PD astrocytes did not support the formation of a functional BBB in an in-vitro BBB model using induced pluripotent stem cells (iPSCs) and microfluid technologies [173]