glutathione transferase pathway

glutathione transferase pathway The role of glutathione-S-transferase in anti-cancer drug resistance Frontiers | Glutathione S-Transferases: Role

Name: glutathione transferase pathway The role of glutathione-S-transferase in anti-cancer drug resistance Frontiers | Glutathione S-Transferases: Role
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Frontiers Glutathione S Transferases: Role in Combating Abiotic Stresses Including Arsenic Detoxification in Plants The role of glutathione S transferases in human disease pathogenesis and their current inhibitors ScienceDirect Glutathione metabolic pathways. GCL, glutamate cysteine ligase; GST, Download Scientific Diagram Glutathione Dependent Pathways in Cancer Cells

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Tissues were stored at -80C until analysis

122,123,124 Gln enters the cell via the amino acid transporter ASCT2/SLC1A5 and is converted to glutamate in the mitochondria by a deamination reaction involving glutaminase (GLS)

Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis