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Creatinine levels typically rise when: the kidneys cannot filter it efficiently due to reduced glomerular filtration rate (GFR), dehydration temporarily reduces renal blood flow, creatine supplements increase creatine turnover, intense exercise or large muscle mass increases baseline production, or certain medications (like NSAIDs or contrast dye) reduce kidney blood flow

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Together, these results demonstrate that neutrophil-intrinsic expression and caspase-3-dependent activation of XKR8 are critical for NET formation in vivo during LPS-induced ALI model