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At the molecular level, TLR signaling is critically dependent on adaptor proteins, primarily myeloid differentiation primary response 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon- (TRIF), which determine the specificity, magnitude, and temporal dynamics of downstream inflammatory responses

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Outside of Egypt and Georgia, most treated patients were in high-income countries in years 2014-2018 where drug sales data were available and analyzed to determine annual treated patients by regimen