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On one hand, it activates the Nrf2 pathway via VDR, inducing the expression of antioxidant enzymes such as superoxide dismutase (SOD), GPX, and CAT to increase ROS scavenging, while simultaneously downregulating iNOS and NADPH oxidase to limit ROS production ( 2+ CAMKK2AMPK signaling pathway ( Clinical and preclinical studies support these antioxidant effects

For instance, experimental evidence suggestive for SSc having a paraneoplastic origin has been provided in association with mutated RNA pol III antigen [38]

Meanwhile, mTORC1/S6K1 can also phosphorylate IRS-1 serine, thus block its activation 80 (Fig

Zhang Y, Wu Y, Zhang M, Li Z, Liu B, Liu H, et al