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In their review, Du, Cullen and Buettner described that the concentration of dianionic ascorbate increases by a factor of 10 for every pH unit increase (Du et al., Clinical perspective Given the effect of vitamin C on normal physiology, it is apparent that it plays a role in the maintenance of homeostasis

In summary, the clinical translation of peptide therapeutics for alopecia requires overcoming substantial hurdles related to physicochemical stability, permeability, specificity, immunogenicity, and regulatory compliance

[DOI: 10.1056/NEJMra051884] [DOI] [PubMed] [Google Scholar] 45.Boyle AJ, Sweeney RM, McAuley DF

Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells