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However, the prodrug technology still faces three key challenges in achieving precise treatment: off-target activation risks (such as premature release due to liver metabolism), tumor microenvironment [8] heterogeneity (such as the uneven distribution of hypoxia levels within the tumor, which hinders the effective release of hypoxia-activated prodrugs [9] and leads to poor treatment efficacy [3]), and insufficient temporal and spatial control accuracy

Inhibition of proliferation of human leukaemia 60 cells by diethyl esters of glyoxalase inhibitors in vitro

McSweeney, M

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