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In the CY 2025 PFS proposed rule (89 FR 61953), we included an example in which CMS receives a severe supply chain disruption rebate reduction request for a Part B rebatable biosimilar biological product on February 15, 2024, and that product is currently in shortage from December 15, 2024 until May 15, 2025

Propofol prevents human umbilical vein endothelial cell injury from Ang II-induced apoptosis by activating the ACE2-(1-7)-Mas axis and eNOS phosphorylation