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Pain Conditions (Non-Diabetic) General nerve, muscle, and joint pain: A study in Italy among 210 men and women with mild to moderate nerve, muscle, or non-inflammatory joint pain without a known cause compared 400 mg of alpha-lipoic acid, 800 mg of alpha-lipoic acid, or placebo, taken once daily for two months

All metrics show improvement in Figure 3G , with average gains ranging from 6%-20%

the substrate was a 4-(chloromethyl)oxetane-2-one racemate, which was converted into a mixture of (R)-4-chloro-3-hydroxybutyric acid and residual (S)- -lactone as illustrated by scheme 2 below