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To address this problem, researchers developed JHU-083, a prodrug form of L-DON, which is selectively activated to L-DON after entering the TME, thus reducing its systemic toxicity and improving its anti-tumor immune response [113, 114]

On non-exercise days, participants took their supplement in the morning with breakfast

However, the VA National Criteria for Use guidelines for checkpoint inhibitor initiation explicitly allow use only for ECOG performance status score of 0 or 1 for all immunotherapy agents, with some exceptions for ECOG performance status score of 0 to 2 for nivolumab and pembrolizumab

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