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In neuroblastoma cells, Epitalon reduced levels of 8-hydroxydeoxyguanosine (8-OHdG), a key marker of oxidative DNA damage that accumulates in aging neurons and is elevated in Alzheimers and Parkinsons disease [51]

After reaching confluence, cells were grouped and treated as aforementioned

Hydrogen bonds were determined on UCSF ChimeraX 1.7.1 software with distance tolerance of 0.400 and angle tolerance of 20.000 62

Under hyperhomocysteinemia, the depletion of CBS and CSE enzymes takes place, which further causes a reduction in the amount of hydrogen sulfide (H2S), resulting in vascular abnormalities due to the impairment of endothelium