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10.1007/s00395-023-00977-4 20 DongY.LiS.LuY.LiX.LiaoY.PengZ.et al (2020)

One of the most potent natural activators of the AKT signaling pathway

moisture causes clumping/oxidation

Further experiments revealed that hydrogen-induced Nrf2 can directly bind to NF-B p65, interfering with its DNA-binding ability to pro-inflammatory gene promoters while also suppressing the release of inflammatory mediators such as HMGB1 and TNF-, thereby truncating the positive feedback loop of IKK