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The ideal candidate is someone who has a meaningful fat-loss goal, defined as 20 lbs or more to reduce, who is also concerned about how skin quality and connective tissue integrity will hold up through that process

Notice Resistance 00:54:05 Cognitive Challenges, Walking, Screens, Tool: Sitting with Boredom 01:01:53 Capturing Ideas, Attractor States, Tool: Being in Nature 01:06:50 2% Rule, Rites of Passage, Tool: Misogi Challenge 01:14:12 Phones, Sharing with Others, Social Media, Tool: Reflection vs Screen Time 01:23:23 Dopamine, Spending vs Investing, Guilt 01:29:48 Sponsor: Function 01:31:35 Relaxation, Shared Identities & Community, Music, Tool: In-Person Meeting 01:38:58 Loss of Gathering Places, Internet & Distorted Views, Hitchhiking 01:45:06 Misogi & Entry Points

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Pivotal ECM components including collagen, fibronectin, and proteoglycans are upregulated in UFs compared to the adjacent myometrium (reviewed in Islam et al., 2018) and may be responsible for the increased tissue stiffness and decreased stretch