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however, major variations were identified in helix H9 and the upper part of helix H4 that affect the size of the active site pockets, substrate recognition and the catalytic mechanism

To explore the antiviral synergy of these two drugs in vivo and to recapitulate the scenario in which most patients with COVID-19 will be treated after the onset of disease, we gave SARS-CoV-2-infected hamsters oral clofazimine and intraperitoneal remdesivir together: the first doses were given 24 h after virus challenge

Affinity purification of proteins and antibodies can be done with either regular agarose beads or magnetic agarose beads

Petruzzelli and Polishchuk, 2019)