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Analysis of our RNA sequencing data revealed a trend toward increased expression of key antioxidant genes, including GSTA14 and TXNRD1, after metformin treatment (Supplementary Fig

The prominent ribosomal decay occurring in ACT-treated WT cells was partially rescued in the ATP6AP1 KO cells at both steady-state and native assembly (Fig

Conclusions Taken together, our data demonstrate that IL-4 / mice are protected from APAP-induced liver injury due to reduced depletion of glutathione, which prevented liver damage and tissue inflammation