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[1] Osteoporosis (hepatic osteodystrophy) and hypothyroidism are also associated with PSC

This upregulation may reflect the cellular attempt to maintain cystine import for glutathione biosynthesis under conditions of heightened oxidative challenge

Notably, the mitochondrial uncoupling agent FCCP, which diminishes mitochondrial membrane potential and ATP production, did not influence cuproptosis, implying that ATP synthesis is dispensable for this process