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Pregnant or breastfeeding women Individuals with a history of medullary thyroid carcinoma (MTC) Patients with multiple endocrine neoplasia type 2 (MEN2) Children and adolescents Those with significant GI motility disorders (unless cleared by a physician) Possible Side Effects of Cagrilintide Cagrilintide is generally well tolerated, but may cause: Nausea (dose-related) Decreased appetite Mild headache or fatigue GI side effects often resolve with slow dose titration

While GLP-1 therapies work through incretin pathways, cagrilintide activates amylin receptors located in key metabolic control centers of the brain[2]

Two carriers to deliver them

In additional experiments, the researchers modified liposomes by adding the cyclic peptide to the surface of liposomes thereby creating 150 nanometer-sized artificial nanoparticles