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Endothelial overexpression of CYP2J2 showed neuroprotective effects against I/R injury by increasing circulating 14,15-EET to enhance regional cerebral blood flow and decrease reactive oxygen species production, the benefits of which were shown to be closely correlated with the activation of PI3K (phosphoinositol 3 kinase)/AKT (protein kinase B) signaling

Side groups direct primarily biological effects, serve as hydrogen acceptors or donators, and determine solubility if a substance is lipophilic or hydrophilic

Optimal neurotransmitter levels are crucial for cognitive processes such as attention, memory, and mood regulation