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10.4093/dmj.2018.0090 83 LeeY.-S.LeeD.ParkG.-S.KoS.-H.ParkJ.LeeY.-K.et al (2021)

The existing findings from epigenetics research need to be appraised in the context of well-known technical limitations epigenetics, such as the blood-brain inconsistencies, tissue-type specificity (Bakulski, Halladay, Hu, Mill, & Fallin, Reference Bakulski, Halladay, Hu, Mill and Fallin2016

Thus, the brain is more susceptible to diseases like Alzheimers disease (AD), which is closely associated with oxidative damage

362 NAD + deficiency correlates with disturbed circadian clocks during aging Besides mitigating the oxidative damage, NAD + can extend lifespan by driving the circadian rhythms