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Anytime, situations in case of the distortion due to imbalance between enzymatic and nonenzymatic antioxidants and oxidants which lost one of paired electrons in the atomic level mean reactive oxygen species (ROS) withal reactive nitrogen species (RNS) in favor of oxidants that are related to oxidative stress

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Unlike other forms of regulated cell death, ferroptosis does not rely on a single dedicated executioner protein but instead reflects the balance between pro-oxidant metabolic processes and multilayered defense systems that limit oxidative membrane damage