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When the mutant protein gets broken down into small pieces in the brain, these pieces clump together in neurons and keep them from functioning normally, ultimately killing the neurons

Furthermore, it has been revealed that the abundance and localization of histone modifications are responsive to various environmental stimuli, such as diet, which can also affect gene expression and lifespan

The pain is worst in the metacarpophalangeal and proximal interphalangeal joints and is especially prominent in the early morning

This yields (i) the membrane lipid component, diacylglycerol (DAG), and (ii) the soluble cytoplasmic component, inositol 1,4,5-tris phosphate (IP3)