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One study found that paracetamol t 1/2 was prolonged in very early pre-terms (2832 weeks gestational age), suggesting that the dose interval may need to be extended in this group, although only a single dose was given [47]

Nevertheless, under physiological conditions, in most tissues mitochondria are the major contributors to the cellular ROS production [28,29,30,31], mainly as a side effect of aerobic respiration via oxidative phosphorylation (OXPHOS) occurring on the inner membrane of the mitochondrion [32, 33], but also through other metabolic routes, such as pentose-phosphate pathway and glutathione (GSH) metabolism [34]

The intact sucrosome vesicles facilitate absorption through both paracellular and transcellular routes, potentially involving uptake by enterocytes and M cells (2729, 37)