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interruption of mAKAPAC5 complexes could be targeted therapeutically to reduce cAMP generation and hypertrophy in cardiac myocytes (Kapiloff et al., 2009)

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Example: 200-pound person 2.7 mg x 200 = 540 mg per day in divided doses 4.5 mg x 200 = 900 mg per day in divided doses Magnesium toxicity is extremely rare, except in people with kidney failure