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The identified pathways, and their metabolites, were known to be involved in ALS pathological mechanisms 25 , thus representing possible new targets for innovative therapeutics

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Is the angiogenesis concern worth monitoring

Of course, if cramps are severe, frequent, persistent, respond poorly to simple treatments, or are not associated with an obvious cause, then the patient and the doctor need to consider the possibility that more intensive treatment is indicated or that the cramps are a manifestation of another disease