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Moreover, exposing mice to a low dose which reflects a typical American diet (0.01 mg/kg/day), caused gut microbiota alterations across two generations-consistent with earlier findings, Akkermansia muciniphila was depleted, while ParaBacteroides distasonis and Christensenellaceae were elevated in the second generation (Barnett et al., 2024)

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223 Under hypoxic pressure, autophagy orchestrates selective degradation of cellular components, including mitochondria (mitophagy), ER (ER-phagy), lipid droplets (lipophagy), ribosomes (ribophagy), nuclei (nucleophagy), and peroxisomes (pexophagy), 224,225,226,227 thereby sustaining tumor metabolism and viability

Once I push through that challenge, the rest of the day feels less daunting