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Conclusion Multidrug resistance to chemotherapy drugs is one of the main obstacles in human cancer chemotherapy and has prompted intense research into discovering novel and innovative mechanisms that can overcome this barrier

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Semaglutide (Wegovy) FDA-approved for: Chronic weight management Treatment of Metabolic dysfunction-Associated Steatohepatitis (MASH) approved August 2025 FDA-indicated for: Reducing risk of heart attack, stroke, and cardiovascular death in adults with established cardiovascular disease who are obese or overweight Weekly injection Clinical trials show an average weight loss of 1215% of body weight

Effect of semaglutide was weaker than that of tirzepatide