glutathione peroxidase ppt Phospholipid Hydroperoxide - an overview The Selenoprotein Glutathione Peroxidase 4:

Model and physiological GSSR substrates are, for example, l-cysteine-glutathione disulfide (GSSCys) 9,10,11,12,13,14,15 , coenzyme A-glutathione disulfide 3,16 , as well as S -glutathionylated serum albumin 9,11,17,18,19,20 , sirtuin 21 , sulfiredoxin 22 , and peroxiredoxins 23,24,25,26,27,28,29

An adequate and stable amount of glutathione in the body does not allow the accumulation of hydrogen peroxide, which can result in cell damage (Brodzka et al

Cancer cells produce significantly higher amounts of ROS than normal cells and therefore administration of prooxidant agents capable of further increase of ROS may represent a potential anticancer approach

In addition, it has been described that oxidized cardiolipin modulates the biophysical properties of OMM to allow oligomerized Bax to insert and permeabilize the OMM (Mari et al., 2008