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Moreover, the LN microenvironment accelerates epigenetic (60) and metabolic reprogramming of cancer cells (61, 62) that promote resistance to ferroptosis, enhancing survival and metastasis through the blood (62)

Finally, PPIs inhibit lysosomal acidification by suppressing the neutrophil vacuolar-type H + ATPase (V-ATPase), which ultimately reduces neutrophil antibacterial activity (Song et al., 2017)