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In the subject with the aberrant cortisol pattern (Hortense), higher urinary cortisol levels were found during the control than the test day and no urinary stress response was found during the test day

doi: 10.1016/j.xcrm.2021.100398 228 van den BoschA

Protection of the BBB, the inhibition of the elements of the brain microvascular damage such as impairment of tight junctions, increased vesicular transcytosis, production of various cytokines, chemokines and reactive oxygen species offers novel therapeutic targets [11]

Notably, some studies have used zinc doses exceeding the recommended upper limit of 40 mg/day [106,107,110,112,113,115,119,120]