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The Panel also reviewed real-world use concentration data submitted by the industry, finding cosmetic products using these peptides at concentrations up to 1% in leave-on products, the same order of concentration used in this category of serum generally

Another significant obstacle is the permeability of the bloodbrain barrier, as many small compounds that demonstrate strong in vitro efficacy have limited exposure to the central nervous system (CNS) in vivo, necessitating high doses that may increase systemic toxicity

Its been studied primarily in animal models, where research has shown some compelling findings: What the research shows: A 2003 study in the Journal of Orthopaedic Research found that BPC-157 accelerated Achilles tendon healing in rats by promoting tendon-to-bone healing and improving biomechanical properties of the repaired tissue