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McKinney-Aguirre et al., 2024)

Physicians India 65 , 6073 (2017)

Brown and his colleagues thought the cell counter machine was incorrect because the patients cell counts were over 23x the average patients counts (which is normally 150 million cells)

Nevertheless, based on the switch in the two substrate-binding affinities (increased K m,GSH and decreased K m,CDNB ) and the significant recovery of GST activity and catalytic efficiency, the double mutant D101N/Q108F and the quadruple mutant of S-crystallin would seem to result in a GST-like S-crystallin that has recovered GST activity and probably a more flexible active site 17