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The oxido-metabolic driver atf4 enhances temozolamide chemo-resistance in human gliomas

In patients with HPV infections, the plasma levels of pro-inflammatory cytokines such as IL-6, IL-8, TNF, macrophage inflammatory protein 1 alpha (MIP-1), granulocyte-macrophage colony-stimulating factor (GMCSF), IL-1, and IL-1 are markedly elevated, followed by a decreased lymphoproliferative response [13]

The stable binding in this position originates from - stacking interactions between ring A of EGCG and F98, ring B and F87, a hydrogen bond between one of the hydroxyl groups of ring B and Q38, which is stable during the MD simulation, and electrostatic interactions between R45 and one of the hydroxyl groups of ring D of EGCG

Its worth noting that this argument is one that NPA has some experience with