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Description

iMQT_020 and the positive control drugs were prepared at 10.2, 30.8, 92.5, 277.7, 833.3, and 2500 g/mL, and 2 g/mL 2-NF was prepared for TA98 cells without S9, 0.5 g/mL 2-AA was prepared for TA98 cells with S9, 0.1 g/mL 4-NQO was prepared for TA100 cells without S9, and 1.25 g/mL 2-AA was prepared for TA100 cells with S9

The compound of (2-(1 H-pyrrol-2-yl)benzo[d]oxazol-6-yl)(morpholino)methanone ( 36 ) showed the best inhibition profile (K i : 7.74 0.75 nM) (Table 1)