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Immunology 49 , 471479 (1983)

Most experts recommend 4 to 8-week cycles rather than continuous use, as long-term human safety data is not available

Blocking the transmission of the HGF/c-MET pathway in CAFs has been demonstrated to impede the movement of CRC cells driven by RAB31 expression, highlighting the role of CAFs in enhancing paracrine HGF release and stimulating the HGF/c-MET pathway, which in turn propels tumor growth [48]