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Z., Holmes, J

Head Neck 41(5):1270-1276, 2019

Huntington's disease (HD) HD is an inherited neurodegenerative disorder characterized by neuropsychiatric symptoms, movement disorders (most commonly choreoathetosis) and progressive cognitive impairment

At the level of the mitochondrial inner membrane ETC, BDNF upregulates the expression of Nicotinamide adenine dinucleotide (NADH): ubiquinone oxidoreductase core subunit S1 (NDUFS1, a subunit of complex I) and cytochrome C oxidase subunit 5B (COX5B, a subunit of complex IV) via TrkB-mediated phosphorylation of cAMP-response element binding protein (CREB), restoring the activity of mitochondrial complexes I/IV in PD models [94, 95]