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Moreover, in an in vitro model of blast-induced auditory hair cell damage, 3-AB inhibition of PARP1 reduced oxidative stress markers, upregulated antioxidant defenses, and helped maintain cell viability by preserving ATP pools 175

doi: 10.1038/414813a

Researchers are investigating whether NNMT inhibition modulates the cellular metabolic responses to repeated contractile stress, potentially explaining the differential metabolic profiles observed when combining NNMT inhibition with exercise protocols in research models