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In female CD-1 mice (which are genetically diverse and comparable to the general population), rifampicin induced tight junction disruption and cholestasis indicated by increased serum levels of total bile acids, supporting potential regurgitation of bile into plasma as a result of leaky tight junctions [100]

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This study concluded that nerolidol in the nano formulation has better neuroprotective abilities than the conventional form at the same dose owning to the enhanced ability to cross BBB due to its higher lipophilicity and the smaller particle size [32]

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