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7 Researchers from the 2020 study also noted that the increase in vitamin B12 was likely unrelated to typical dietary intake or standard supplementation because food and supplements generally do not substantially affect plasma B12 concentrations

Extremely high plasma glycine concentrations may lead to hyperglycinemia and, via catabolism, hyperammonemia, potentially causing neurological symptoms such as headache or confusion-though such events are exceedingly rare outside massive irrigant absorption

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