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Association of age with differences in immune related adverse events and survival of patients with advanced nonsmall cell lung cancer receiving pembrolizumab or nivolumab

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Receptor tyrosine kinases (RTKs), insulin and insulin-like growth factor 1 (IGF-1), WNT and tumor necrosis factor (TNF), inflammatory cytokines, and RAS activate multiple signaling pathways that converge on a major upstream inhibitor of mTORC1, the TSC complex, which is composed of TSC1, TSC2, and TBC1D7