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He stressed that the amount of acetaminophen ingested is open to question since alcoholics are notoriously unreliable informants. But if accurate, he wrote, the amount of acetaminophen that harmed those 18 patients bring us uncomfortably close to the maximum recommended daily dose

In acute pancreatitis, early trypsin activation leads to autodigestion, causing extended inflammation and SIRS, which may progress to MODS [6, 65]

This helps identify instability issues early in the design process